Monitoring the penetration process of single microneedles with varying tip diameters
نویسندگان
چکیده
منابع مشابه
Monitoring the penetration process of single microneedles with varying tip diameters.
Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles. The present study was designed to monitor both penetration depth and force of single solid microneedles with various tip diameters ranging from 5 to 37µm to provide insi...
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The main purpose of the present work is multi-objective shape optimization of a projectile tip for impacting and normal penetrating. Velocity drop, weight and inner volume of projectile have been considered as three conflicting objective functions. For this purpose, at the first step, finite element modeling was done using ABAQUS/Explicit and projectile penetration was examined in different ge...
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This study was designed to investigate the penetration and the distribution of poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles in the human skin treated with microneedles. Fluorescent nanoparticles were prepared to indicate the transdermal transport process of the nanoparticles. Permeation study was performed on Franz-type diffusion cells in vitro. The distribution of nanoparticles was v...
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ژورنال
عنوان ژورنال: Journal of the Mechanical Behavior of Biomedical Materials
سال: 2014
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2014.09.015